Kev nce qib hauv kev kho mob thev naus laus zis tau ua rau kev txhim kho cov kev kho mob tshiab rau cov kab mob neurological. Ntawm cov no yog arteriovenous malformations (AVMs), uas yog pathological tangles ntawm cov hlab ntsha thiab cov hlab ntsha hauv lub hlwb uas tuaj yeem ua rau muaj teeb meem loj xws li aneurysm rupture, stroke, lossis hemorrhage. Nws yog kev txhawb kom pom cov kev tshawb fawb tsis ntev los no ntsuas qhov ua tau zoo ntawm onyx kua embolic cov neeg ua haujlwm hauv kev kho mob intracranial AVMs, qhia txog qhov kev xav zoo hauv kev kho mob ntawm cov xwm txheej nyuaj.
Lava kua embolic cov neeg ua haujlwm yog tsim los ntawm ethylene vinyl cawv (EVOH) copolymer yaj hauv dimethyl sulfoxide (DMSO) thiab tau siv rau hauv kev kho mob endovascular ntawm AVMs. Lub cim tshwj xeeb ntawm Lava uas ua rau nws sib nrug los ntawm lwm cov tshuaj embolic yog nws lub peev xwm nkag mus tob rau hauv AVM nidus, lossis hauv nruab nrab cov tub ntxhais kawm, thiab tsim ib qho chaw ruaj khov nyob ib ncig ntawm cov hlab ntsha, cuam tshuam cov ntshav txaus. Cov yam ntxwv no ua rau Lava qhov kev xaiv zoo nkauj rau AVM kev kho mob, vim nws tuaj yeem txo qhov tshwm sim ntawm hemorrhage lossis rupture thiab tej zaum yuav ua rau tag nrho obliteration ntawm malformation. Dhau li ntawd, LAVA Liquid Embolic System muaj nyob rau hauv peb cov khoom tsim, LAVA-12, LAVA-18 thiab LAVA-34. LAVA-12 raug pom zoo thaum pub mis rau cov menyuam yaus thiab los ntawm cov khoom me me. LAVA-18 raug pom zoo thaum noj tshuaj pedicle yuav tsum tau ua nyob ze rau ntawm nidus. LAVA-34 yog pom zoo rau embolizing siab dua ntws thiab loj fistulous Cheebtsam.
Qhov kev sim tshuaj tshiab tshaj plaws tau pom tias 105 tus neeg mob uas tau tso npe kawm (53 qhov xwm txheej hauv pawg xeem thiab 52 tus neeg mob hauv pawg tswj hwm) tau ua tiav thiab tshem tawm kom zoo, thiab qhov kev ua tiav ntawm embolization yog 100%. Cov kws kho mob tau soj ntsuam qhov ua tau zoo thiab kev nyab xeeb ntawm Lava hauv kev kho AVMs. Zuag qhia tag nrho, qhov ua tiav obliteration tus nqi tau pom nyob rau hauv 100% ntawm cov neeg mob, tsis muaj cov neeg mob tuag los yog loj mus tas li neurological deficits qhia. Thaum cov txiaj ntsig no tau cog lus tseg, nws tseem ceeb heev uas yuav tsum nco ntsoov tias kev kho AVM yuav tsum muaj kev qhia dav dav uas yuav suav nrog ntau yam kev hloov pauv, nyob ntawm tus neeg mob qhov tshwj xeeb.
Lava kua embolic cov neeg ua haujlwm tau tshwm sim los ua qhov kev xaiv zoo rau kev kho mob intracranial arteriovenous malformations. Txawm hais tias kev tshawb fawb ntxiv yuav tsum tau soj ntsuam tag nrho cov kev ua tau zoo thiab kev nyab xeeb ntawm kev kho mob no, cov txiaj ntsig ntawm kev tshawb fawb tsis ntev los no tau txhawb nqa. Nrog txuas ntxiv kev nce qib hauv kev kho mob thev naus laus zis thiab kev nkag siab ntau dua ntawm qhov nyuaj ntawm AVMs, kev pom zoo rau cov neeg mob uas muaj cov mob no yog qhov zoo. Cov kua embolic cov neeg ua haujlwm muaj kev cog lus thiab muaj txiaj ntsig zoo rau kev kho mob ntawm intracranial arteriovenous malformations. Lawv muab kev xaiv tsawg kawg nkaus rau kev kho AVMs, nrog rau kev ua tau zoo ntawm kev ua tau zoo, txo kev pheej hmoo ntawm cov teeb meem, thiab cov txiaj ntsig zoo. Raws li nrog rau txhua yam thev naus laus zis, cov tshuaj ua kua embolic yuav tsum ua raws li cov lus qhia nruj, paub txog lawv txoj kev siv, thiab kev sib koom ua ke ntawm neuroradiologists thiab neurosurgeons. Nrog rau kev nce qib thev naus laus zis tsis ntev los no hauv cov kua embolic cov neeg ua haujlwm, nws zoo li lawv yuav txuas ntxiv ua lub luag haujlwm tseem ceeb hauv kev kho AVMs.